Jan Vertonghen's hamstring injury will keep him out until December, Tottenham have confirmed.
The left-sided defender joined Dele Alli and Christian Eriksen on the sidelines when he was forced off at half-time of the 2-0 win at Huddersfield Town at the end of September.
Belgium boss Roberto Martinez last week drew criticism from Mauricio Pochettino for revealing Vertonghen was likely to miss November's Nations League matches.
The club's updated timeframe now rules the 31-year-old out of key Premier League fixtures against Manchester City and Chelsea, while his involvement in the derby with Arsenal on December 1 is also in doubt.