Uruguay will be aiming to book their place in the Copa America knockout stages when they take on Japan in Porto Alegre on Thursday.
La Celeste ran out emphatic 4-0 winners over Ecuador in their opening match, meaning victory here would ensure a place in Group C's top two with a game to spare.
Latest odds
Having won three of the previous four encounters between this pair, they are 2/11 (1.18) favourites with 888Sport to come out on top at the Arena do Gremio.