Arsenal's north London derby at Tottenham on Sunday has been postponed because the Gunners do not have enough available players to field a side.
"The decision is a result of a combination of Covid-19, existing and recent injuries and players on international duty at the Africa Cup of Nations," said the Premier League.
It is the 21st top-flight game to be postponed this season because of Covid.
Premier League rules say a club must play a game if they have 13 outfield players and one goalkeeper available.
Arsenal have Thomas Partey, Mohamed Elneny, Pierre-Emerick Aubameyang and Nicolas Pepe on Cup of Nations duty, while Cedric Soares, Bukayo Saka and Calum Chambers all picked up injuries in their Carabao Cup semi-final first leg draw against Liverpool on Thursday.