Tottenham and Chelsea will square off for a place in the Carabao Cup final while Manchester City face Burton Albion in the other last-four tie.
A trio of Premier League clubs are left standing in the competition but at least one will be eliminated when Spurs - 2-0 winners at north London rivals Arsenal in the quarter-finals - take on Maurizio Sarri's side, who edged Bournemouth 1-0 at Stamford Bridge.
Heung-Min Son and Dele Alli provided the goals for Spurs at the Emirates Stadium on Wednesday, while Chelsea prevailed thanks to Eden Hazard's late strike.
Tottenham will host the first leg as they seek to avenge the 2015 final defeat they suffered at the hands of the Blues.