Son Heung-min is set to lead the line for Tottenham after scoring a late winner at Swansea but Hugo Lloris could miss a second game due to illness.
Victor Wanyama may return after a back injury but Harry Kane and Danny Rose remain out.
Miguel Britos begins a two-match ban for his red card against West Brom, leaving Watford short of defenders.
Sebastian Prodl is out with a rib problem, while Younes Kaboul is another absentee because of a hamstring injury.
WHAT THE MANAGERS SAY
Tottenham manager Mauricio Pochettino on the late win over Swansea: "If you compare Chelsea and Tottenham over the last 10 years, it is true Chelsea won more titles.