Tottenham manager Mauricio Pochettino is expected to pick Son Heung-min in place of injured striker Harry Kane.
Midfielder Mousa Dembele is fit, but Kyle Walker and Victor Wanyama are doubts with minor knocks.
Southampton manager Claude Puel has no fresh injury worries and he could pick the same team that beat Watford.
Striker Charlie Austin is edging closer to a return from a shoulder problem, but defender Virgil van Dijk remains a long-term injury absentee.
MOTD COMMENTATOR'S NOTES
Simon Brotherton: "Last week's FA Cup thrashing of Millwall came at a heavy price for Tottenham, who now face four to six weeks without their star striker Harry Kane.