Winger Luciano Narsingh is available to make his first Swansea appearance since joining from PSV Eindhoven after recovering from a calf problem.
Ki Sung-yueng returns to the squad following a calf injury, but Leon Britton and Oliver McBurnie are out.
Southampton manager Claude Puel says defender Virgil van Dijk's ankle injury will rule him out for "a few weeks".
However, Puel wouldn't reveal whether any of his other injured players would return against the Swans.
James Ward-Prowse, Sofiane Boufal, Jay Rodriguez, Charlie Austin, Jeremy Pied, Matt Targett and Alex McCarthy were all absent at the weekend when Saints lost 5-0 to Arsenal in the FA Cup.