Swansea winger Jefferson Montero may make his first league start of the season after overcoming a calf injury.
And Kyle Naughton has recovered from the illness which forced him off in Monday's 3-1 defeat at Stoke.
Man Utd midfielder Paul Pogba is a doubt after being forced off during midweek with an apparent thigh injury.
Ander Herrera will miss the game through suspension while manager Jose Mourinho is also serving a one-match touchline ban.
MOTD COMMENTATOR'S NOTES
Steve Wilson: "Since the end of August, Manchester United have lost more than they've won in all competitions - hardly what their dreams were made of when Mourinho, Zlatan and Pogba were employed.