Swansea winger Nathan Dyer has had surgery to remove extra bone growth on his ankle and is likely to be sidelined until mid-November.
Record signing Borja Baston could make his full Premier League debut after starting in midweek in the EFL Cup.
Manchester City forward Sergio Aguero returns after a three-match domestic ban, while David Silva could be fit.
Vincent Kompany is a doubt after being injured in midweek during his first game after a five-month lay-off.
MOTD COMMENTATOR'S NOTES
Jonathan Pearce: "It would be a major shock if Pep Guardiola fails to make it a perfect 10 after his club record run, for a new manager, of nine victories in his nine opening matches in charge.