Swansea full-back Neil Taylor is ruled out after fracturing his cheekbone in training.
Luciano Narsingh, who has joined from PSV Eindhoven, is not available for his debut because of a calf injury.
Arsenal midfielder Mesut Ozil returns after missing three games through illness but Hector Bellerin and Francis Coquelin are ruled out.
The Gunners are also without Mohamed Elneny, Theo Walcott, Santi Cazorla, Per Mertesacker and Kieran Gibbs.
Petr Cech, Laurent Koscielny and Alexis Sanchez are expected to be recalled after being rested against Preston in the FA Cup.
MOTD COMMENTATOR'S NOTES
Simon Brotherton: "Officially, this is Paul Clement's first league game in charge, with Arsenal providing the opposition - just as they did at the start of predecessor Bob Bradley's short reign.