Manchester United held out for a battling 0-0 draw the last time they went to Anfield but can Ruben Amorim's struggling side stop Premier League leaders Liverpool this time?
"If you are United, you are praying for a narrow defeat," said BBC Sport's football expert Chris Sutton.
"There is not a single United fan who thinks they will get anything from this game, and you fear for what this Liverpool team could do to them."
Sutton is making predictions for all 380 Premier League games this season, against a variety of guests.
His guest for week 20 will be announced on Friday.