The Saints host the Eagles in a game that could see either team move six points clear of the relegation zone
Both managers will have this game marked down on their calendars as a must win as both Crystal Palace and Southampton flirt with relegation.
Tuesday's results will have both managers sweating after Burnley, Newcastle and Fulham all picked up unlikely points.
Southampton were the victors when the two sides met earlier in the season as the game ended 2-0 with goals from Danny Ings and Pierre-Emile Hojbjerg.
Editors' Picks
| Game | Southampton vs Crystal Palace |
| Date | Wednesday, January 30 |
| Time | 7:45pm GMT / 2:45pm ET |
TV Channel, Live Stream & How To Watch
In the United States (US), the game can be watched live and on-demand with NBC Sports Gold
In the United Kingdom (UK), the game will not be broadcast live.