Southampton boss Claude Puel is set to restore a host of players to his first XI after resting them for the Europa League win over Sparta Prague.
Striker Charlie Austin scored twice in that match but Puel has refused to guarantee him a starting place.
Swansea's record signing Borja Baston may be on the bench for the first time after a thigh injury delayed his debut since a move from Atletico Madrid.
Winger Nathan Dyer has been ruled out for two months due to an ankle problem.
MOTD COMMENTATOR'S NOTES
John Roder: "Southampton fans are in for plenty of blank Saturdays over the next couple of months, as this is the first of seven Sunday Premier League fixtures in a row for the Saints.