Sheffield United should welcome back a host of players, with George Baldock, Gustavo Hamer and goalkeeper Ivo Grbic likely to be in contention.
Oli McBurnie and Ben Brereton Diaz may also return, with the latter missing last week's win at Luton because of a hamstring strain.
Brighton are boosted by the return of Simon Adingra after his successful Africa Cup of Nations campaign.
However, top scorer Joao Pedro is still sidelined with a hamstring issue.
MATCH FACTS
Head-to-head
- Sheffield United are unbeaten in their past seven league clashes with Brighton, winning four and drawing three.