Jose Mourinho will be without the duo as well as Phil Jones and Matteo Darmian, while Ander Herrera is suspended for Wednesday's game
Manchester United have left Wayne Rooney and Luke Shaw out of their squad that will travel to France to face Saint-Etienne in the second leg of the Europa League round of 32 clash.
Rooney missed the first leg and Sunday's win over Blackburn Rovers with a muscle problem but returned to training ahead of Wednesday's clash.
However, the skipper will play no part and has been left at home, along with Luke Shaw who has once again failed to make the squad.