Wolves say Portugal forward Pedro Neto will miss the 2022 World Cup as he requires an ankle operation.
The Premier League club said that Neto strained his lateral ligaments.
"Following further evaluation and a specialist opinion this week, it is planned for him to undergo surgery," a club statement added.
"This means that, unfortunately, he will not be fit for the upcoming World Cup."
Neto has made three appearances for Portugal and, while he was in their squad for recent Nations League games against the Czech Republic and Spain, he did not play in either.