Both sides bagged vital victories in the Premier League last weekend, with the Magpies enjoying a 1-0 win against Leicester City while Saints were 3-1 winners against Wolves at St Mary's.
Those results, along with Brighton failing to beat Cardiff on Tuesday, means top-flight safety appears to be all but assured for these two teams.
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Before being beaten by Crystal Palace earlier this month, Newcastle had won five successive home matches in the Premier League. William Hill offer 7/5 (2.40) that Rafa Benitez's men take all three points on Tyneside.