Polokwane City are set to take on Highlands Park in the 2019 MTN8 semi-final first-leg match at the Peter Mokaba Stadium on Saturday.
Rise and Shine reached the last four for the first time after stunning the defending champions Cape Town City 2-0 in the quarter-finals.
They are looking to advance to the final in their second appearance in the lucrative tournament.
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On the other hand, Highlands Park caused an upset by defeating nine-time MTN8 champions Orlando Pirates 1-0 in the quarter-finals.
The Lions of the North are now hoping to overcome Rise and Shine and reach the final for the first time.