Mexico continued their winning record under Gerardo Martino, but a 3-1 victory over Venezuela was soured by an injury to Edson Alvarez.
Alvarez came off in the first half at Mercedes-Benz Stadium in Atlanta, where Mexico continued preparations for the CONCACAF Gold Cup.
After Jhon Murillo put Venezuela ahead, Mexico were dominant for the most part, deservedly equalising through Roberto Alvarado.
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Rodolfo Pizarro and Andres Guardado struck after half-time as Mexico made it three from three since Martino took charge in January.
While Mexico put Venezuela under enormous pressure early, they fell behind in the 18th minute.