The world's most expensive player Paul Pogba is expected to make his Manchester United return against Southampton at Old Trafford.
After completing the most protracted transfer saga of the summer, the £100m France international missed United's opening day 3-1 victory over Bournemouth through suspension carried over from the Coppa Italia.
Although United have not beaten Southampton at home since 2013, Jose Mourinho can set a marker by going three points clear at the top of the table with victory.
You can follow Sportsmail's LIVE coverage of the first Premier League game on a Friday this season here.