Manchester United will be without midfielder Marouane Fellaini after his red card in the Manchester derby.
Defender Tim Fosu-Mensah suffered a shoulder problem in that game and joins a lengthy injury list, which includes midfielders Paul Pogba and Juan Mata.
Swansea midfielder Jack Cork and defender Martin Olsson are expected to return after recovering from respective ankle and hamstring injuries.
Wayne Routledge is ruled out after having a hernia operation on Tuesday.
MOTD COMMENTATOR'S NOTES
Simon Brotherton: "Manchester United's push for a top-four finish continues against a Swansea side who are currently two points from safety in their battle to avoid the drop.