Paul Pogba will captain Manchester United while Anthony Martial starts as Jose Mourinho has opted for a much-changed side for the Champions League Group A match against Basel.
It is Pogba's second game back with the Red Devils following a lengthy lay-off with a hamstring injury sustained in the first match against Basel earlier this season.
And Anthony Martial retains his spot after scoring in Saturday's 4-1 Premier League win over Newcastle, with only Pogba, Romelu Lukaku and Chris Smalling backing up with consecutive starts.
Elsewhere there is a recall for Marcos Rojo for a first senior start since damaging ACL ligaments in the Europa League quarter-final second-leg clash with Anderlecht on April 20, while Sergio Romero is given the gloves as David De Gea is rested.