Zlatan Ibrahimovic is set to return for Manchester United after completing a one-match domestic suspension.
Wayne Rooney and Henrikh Mkhitaryan could also start after impressing against Feyenoord, but Eric Bailly and Chris Smalling remain injured.
West Ham captain Mark Noble is available after serving a ban but defender Winston Reid misses out because of his red card at Tottenham.
Pedro Obiang is expected to be fit despite an ankle injury.
MOTD COMMENTATOR'S NOTES
Guy Mowbray: "I can't be alone in having casually thought that West Ham tend to do well at Old Trafford, only to be proved wrong when looking back at results.