The Red Devils will have to make do without the defensive duo for some time while midfielder Paul Pogba is also still sidelined
Jose Mourinho has confirmed Chris Smalling and Phil Jones are out with "long-term injuries", but Wayne Rooney is in line to face West Brom on Saturday.
Smalling pulled out of the England squad after playing in a friendly defeat to Germany, while Jones sustained a toe problem after a challenge from his team-mate in training with his country.
Rooney has not played since the start of March with a knee injury but could feature against the Baggies at Old Trafford this weekend, when Paul Pogba (hamstring) will miss out.