Albert Sambi Lokonga was ineligible against parent club Arsenal on Tuesday and could play his first game for Luton since being injured on 23 September.
However, Issa Kabore is on loan from Manchester City and therefore unable to feature against the reigning champions.
Tom Lockyer and Marvelous Nakamba could both return following injuries.
Manchester City welcome back key midfielder Rodri and winger Jack Grealish, both of whom were suspended for Wednesday's defeat at Aston Villa.
Jeremy Doku's availability is uncertain after he missed out in midweek through injury, while Kevin de Bruyne remains a long-term absentee.