Luton captain Tom Lockyer says he would be "at peace" with retirement after his cardiac arrest in December.
Issa Kabore is among seven other players expected to miss the game but Elijah Adebayo could be in contention to start.
Everton pair Dominic Calvert-Lewin and Seamus Coleman are back in training and available, as is Beto after recovering from concussion.
Vitalii Mykolenko and Nathan Patterson are out for the rest of the season.
MATCH FACTS
Head-to-head
- Luton have already beaten Everton twice this season, once in the Premier League and once in the FA Cup fourth round.