Luton welcome back Issa Kabore, who was ineligible to face parent club Manchester City.
The Hatters will monitor Teden Mengi's knee injury but a further 10 players remain unavailable.
Brentford pair Kristoffer Ajer and Christian Norgaard have overcome respective calf and back problems.
Head coach Thomas Frank says Ivan Toney is "progressing" in his recovery from a hip issue but did not say if the striker would be fit to start.
MATCH FACTS
Head-to-head
- Brentford have won six of the past seven meetings, including 3-1 in December's reverse fixture.
- Luton's only league win against the Bees in the past 19 years was by 2-1 in the Championship at Kenilworth Road in February 2020.