Jurgen Klopp's side return to Anfield for the first time since their 2-1 defeat at the Etihad on January 3, and are missing three key defenders
Liverpool will aim to stretch further ahead of Manchester City in the Premier League title race when they take on Crystal Palace at home on Saturday.
City do not play until Sunday when they travel to Huddersfield Town, so Liverpool can reclaim their seven point lead at the top until then at least.
Jurgen Klopp's side were not at their fluent best against Brighton last time out, only beating the Seagulls 1-0 at the Amex Stadium thanks to a second-half penalty from Mohamed Salah.