Laurent Koscielny and Sokratis Papastathopoulos left Friday's FA Cup clash with Manchester United due to injury, further worsening Arsenal's defensive crisis.
Arsenal recently lost Hector Bellerin to injury as the fullback has been ruled out for up to nine months after rupturing his anterior cruciate ligament.
On Friday, Koscielny was at the center of a collision with Romelu Lukaku, as the Manchester United forward's foot collided with the Frenchman's head.
Lukaku immediately signaled to the physio, ruling Koscielny out after a lengthy delay in play.
The incident came after Sokratis was also knocked out of the match after falling awkwardly on his ankle while competing for a ball against Jesse Lingard.