David Meyler will play no further part in Hull's attempt to avoid relegation from the Premier League.
The midfielder has suffered a season-ending medial knee ligament injury.
The 27-year-old midfielder sustained the injury during a routine training session with Marco Silva's side.
Meyler, who has made 28 appearances in all competitions for the Tigers this season has become an important part of the team but will play no further part.
Hull said in a short statement on Friday evening: 'David Meyler will miss the rest of the season after suffering a medial knee ligament injury during training.