Hull captain Michael Dawson is expected to make his first appearance of the season after recovering from knee ligament damage.
Andy Robertson has been ruled out for up to eight weeks with a calf injury, while Moses Odubajo faces a six-month absence because of a fractured kneecap.
Stoke manager Mark Hughes has a potential problem at right-back.
Phil Bardsley will have a hamstring injury assessed, while Glen Johnson remains absent with a thigh problem.
MOTD COMMENTATOR'S NOTES
Martin Fisher: "Hull City's season is quickly plunging into the one many of their fans feared after winning promotion.