Hull striker Dieumerci Mbokani is back in training after a hamstring injury and should be at least fit enough for a place on the substitutes' bench.
Robert Snodgrass is nearing a return from an ankle injury but this game may come too soon for him.
Southampton will recall players such as Jose Fonte, Charlie Austin and Steven Davis, who began on the bench against Inter Milan on Thursday.
Shane Long remains out with a hamstring problem.
MOTD COMMENTATOR'S NOTES
Alistair Mann: "Having accumulated seven points from their opening four games, you could certainly forgive Hull City supporters for beginning to predict this as a positive season of consolidation.