Hull City forward Dieumerci Mbokani is included in the squad to face Arsenal for the first time since joining the club on transfer deadline day.
Ryan Mason and Will Keane are among five other recent signings who could make their home debuts.
Arsenal manager Arsene Wenger could hand Olivier Giroud his first start of the season and recall Granit Xhaka.
Aaron Ramsey, Per Mertesacker, Danny Welbeck and Carl Jenkinson all remain sidelined by injuries.
MOTD COMMENTATOR'S NOTES
Guy Mowbray: "Hull's only victory over Arsenal in 18 meetings since 1915 caused a huge stir eight years ago - but there'd be an even bigger reaction to another win now.