The Ghana winger was on the losing side when the Little Eagles and the Rossoneri came face to face in league action
Emmanuel Gyasi and Spezia suffered their second defeat in four days with a 2-1 home loss against AC Milan in Serie A on Saturday.
Daniele Verde struck for the Little Eagles but goals from Daniel Maldini and Brahim Diaz handed all three points to the Rossoneri at Stadio Alberto Picco.
Spezia have found themselves one point above the relegation zone but risk falling down into the dreaded space when bottom-three Venezia, Cagliari and Salernitana later get their turns of matchday six action.