Constantine are hoping to sensationally overturn the 3-2 away loss they suffered at home last weekend, while Horoya are eager to upset Wydad in Rabat.
Horoya are keen to make Caf Champions League history when they clash with Wydad Casablanca in a quarter-final, second leg match at the Stade Prince Moulay Abdallah on Saturday.
The Guinean champions have never reached the Caf Champions League semi-finals before and are attempting to achieve that feat in Rabat.
Having ended at the quarter-final stage last season, where they were booted out by Al Ahly, Horoya are again 90 minutes away from making history.