Portland overcame a slow start with a monstrous 43-point second quarter and ended up with the 134-106 win.
Damian Lillard paced the Blazers with 35 points including 22 in the first half. He was 9-17 from the field, 4-9 from three and 13-13 from the free throw line.
Blake Griffin, the leading man for the Clippers, had 15 points, six assists and four rebounds.
C.J. McCollum continued his better run of form with 20 points, while Jusuf Nurkiu0107 had 13 points, nine rebounds and fouled out.
Terry Stotts decided to go with Caleb Swanigan and Al-Farouq Aminu as starters.