The Baltimore Ravens experienced the largest Covid-19 outbreak in the NFL to date earlier this season during the week of Thanksgiving, with some two dozen-plus players ultimately being placed on the Reserve/Covid-19 List. The majority of them were announced as having tested positive.
Almost all of them missed their next game, which was postponed for six days. Several of them missed two games, including all four who tested positive within 10 days of the second game who were not on the Reserve/Injured List (and thus would not have played anyway, or have even been eligible to play in the game).