Week 15 of the 2021 NFL season will kick off with a Thursday Night Football matchup featuring the Kansas City Chiefs (-3.5)
(9-4) on the road against the Los Angeles Chargers (+3.5) (8-4).
The Chiefs lead the all-time series between these teams, 64-57-1, but the Chargers have won the past two meetings, including earlier this season in Kansas City, 30-24. The last time they faced off in California was Sept. 2020 in a game that went into overtime, but ultimately ended with a Chargers 23-20 victory.
There has been an evolving COVID situation league-wide this week, resulting in over 90 players ending up testing positive or being named a close contact.