The NFL Week 13 slate of Sunday games will cap off with a Sunday Night Football matchup between the San Francisco 49ers (5-6) on the road against the Buffalo Bills (9-2).
The Bills lead the all-time series between these teams by just one game, 7-6, and have won their past two meetings. They last faced off back in 2020, but it was on the West Coast, with Buffalo winning 34-24 on the road.
Buffalo will definitely have home-field advantage on Sunday night as the area has seen blizzard conditions for the past several days.