The final game of Week 17 will be a Monday Night Football contest between the Detroit Lions (13-2) on the road against the San Francisco 49ers (6-9).
The Niners lead the all-time series between these teams, 38-27-1, and have won 11 of their 12 most-recent regular season meetings. However, they haven’t faced off since 2021, and a lot has changed in Detroit since then. They’ve met three times in the postseason over the years, most recently back in January, when the 49ers barely beat the Lions, 34-31, in the NFC Championship game.