The final game of Week 16 will be a Monday Night Football matchup featuring the Los Angeles Chargers (-6.5)
(8-6) on the road against the Indianapolis Colts (+3.5) (4-9-1).
The Chargers lead the all-time series between these two teams, 17-10, and have won three of their four most recent meetings. They last faced off against each other in September 2019, with the Chargers winning at home, 30-24, in overtime. However, the last time they played in Indianapolis, which was in 2016, the Colts got the home win, 26-22.
The Colts are coming off what started as an incredible momentum building game against the Vikings, only to let Minnesota score 39 points in the second half to complete the biggest comeback win in NFL history.