Derek Barnett is out and fourth-round rookie Josh Sweat, who has played just 15 defensive snaps this season, suddenly finds himself in the defensive end rotation for the Super Bowl champs with Brandon Graham, Michael Bennett and Chris Long.
And while the Eagles' ability to overcome several key injuries and win a Super Bowl last year might make you believe that this team is the NFL equivalent of a starfish, that can lose an arm and simply regenerate another one, there is a limit to their resilience.
And quite frankly, the loss of Barnett just might be the breaking point for Jim Schwartz's defense.