On Friday morning, head coach Doug Pederson officially announced that running back Darren Sproles (concussion) and tackle Halapoulivaati Vaitai (knee) are both out for Sunday's game against Baltimore.
Without Sproles, the Eagles will keep rookie running back Byron Marshall active. Marshall has spent the entire season on the practice squad before being elevated to the active roster earlier this week.
Meanwhile, OL Allen Barbre (hamstring) and WR Jordan Matthews (ankle) are questionable heading into Sunday.
As a precaution, the Eagles practiced with rookie third-round pick Isaac Seumalo at right tackle while Barbre recovers.