Nelson Agholor will miss his first NFL game on Monday against the New York Giants because of an ankle injury. Agholor, the Eagles' first-round pick, suffered the injury in last week's win over the New Orleans Saints and did not practice for much of the week. He was declared out on Saturday.
Linebacker Mychal Kendricks (hamstring), linebacker Kiko Alonso (knee), and defensive end Brandon Bair (groin) are also out.
Ryan Mathews is questionable with a groin injury suffered on Friday.
For the Giants, wide receiver Odell Beckham Jr. is questionable even though he hasn't practiced. Fellow wide receiver Rueben Randle is probable with a hamstring injury.