Isaac Seumalo started at left guard and Avonte Maddox started at safety, representing two notable lineup changes the Eagles made in the 23-21 loss to the Minnesota Vikings on Sunday.
Seumalo replaced Stefen Wisniewski, who started much of last season and was on the offensive line during the Super Bowl run.
"In fairness [to] both Isaac and Stefen, I want to make sure that we evaluate the film on this, and it's going to be hard, though, because it's a short week, short turnaround, and we're on to the Giants," coach Doug Pederson said."I thought initially, [Seumalo] played well.