Forward Cyle Larin and defender Tommy Redding will not travel with Orlando City to Philadelphia for Friday's 7 p.m. match because of injuries.
Larin, the Lions' leading goal scorer, left Sunday's game against Portland early with a hamstring injury. Orlando City coach Adrian Heath said it was not serious, but the club doesn't want to risk worsening a minor injury by pushing him to play too soon.
"We're pretty confident about the game after [Philadelphia], but we'll see," Heath said of Larin's eventual return.
Redding is recovering from a blow to the head that took him out of Sunday's game at halftime.