Pregnon enrolled at Wyoming in 2020 and was unrated by the scouting services. He didn’t play that year in the Cowboys’ covid-shortened season, and redshirted the next season in 2021 with just a single brief appearance.
In 2022, Pregnon started at right guard from the first snap of the opener. In the 3rd quarter of their sixth game against San José State, Pregnon got hurt on a successful 4th & short conversion during a comeback drive (the Pokes then went on four consecutive 1-2-3-punt sequences for the rest of the game in his absence).