Khalil Tate beat Colorado with his legs last year in a record-setting performance.
The Arizona quarterback took down the Buffaloes with his arm in the rematch.
Tate threw for career-high 350 yards and five touchdowns after setting an FBS rushing record against Colorado a year ago, lifting Arizona to a 42-34 victory over the Buffaloes Friday night.
"Khalil ran around and threw it up in the air, and their guys came down with it on long, delayed plays," Colorado coach Mike MacIntyre said. "Those are tough to stop."
Arizona (5-5, 4-3 Pac-12) struggled early while falling into a 10-0 hole, then scored on its next eight possessions.