No. 3 seed Marin Cilic, the 2017 Wimbledon runner-up, was upset in the second round Thursday, leaving a major opening for American John Isner.
Cilic was also the highest seed (and only remaining Grand Slam winner) that Roger Federer could have faced before the final.
Argentina’s Guido Pella, ranked No. 82 in the world, shocked the Croatian Cilic 3-6, 1-6, 6-4, 7-6 (3), 7-5.
Cilic became the fourth top-10 seed in the men’s draw to go out in the first two rounds. Five of the top eight women have also been upset.