Forward Natasha Mack led the Cowgirls (14-12, 5-9 Big 12) with 14 points and 18 rebounds. She also had five blocks.
OSU outscored TCU in the paint but were plagued by poor shooting. The Cowgirls hit just three of 15 shots in the first quarter to fall behind.
Forward Vivian Gray scored 13 points for OSU but was only 4 of 16 from the field, including going 0 of 7 on 3-point attempts. As a team, the Cowgirls made just 1 of 23 shots behind the 3-point line.
Guard Kianna Ray led TCU (20-5, 11-3) with 15 points.